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FLASH GENE
Symbol ANKRD6 contributors: mct - updated : 06-06-2014
HGNC name ankyrin repeat domain 6
HGNC id 17280
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth   highly
Endocrineneuroendocrinepituitary  highly
 thyroid   highly
Nervousbrain    
Reproductivemale systemtestis  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • eight ANK repeats, involved in protein-protein interaction
  • two coiled-coil regions
  • several nuclear localization signals
  • HOMOLOGY
    interspecies ortholog to the Drosophila PCP protein Diego
    intraspecies homolog to ankyrin
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,intermed filament
    intracellular,nucleus
    text
  • intermediate filament protein
  • translocates to the nucleus
  • localizes to the centrosome
  • basic FUNCTION
  • regulates heart formation and gastrulation movements in development
  • acting as a molecular switch, which suppresses Wnt signals mediated by the canonical beta-catenin pathway and stimulates signaling via JNK
  • acts as a molecular switch that blocks beta-catenin-dependent and promotes beta-catenin-independent WNT signaling
  • ANKRD6, and MLLT3 block canonical WNT signaling; however, this occurs independently of each other, and does not require nuclear ANKRD6
  • centrosomal localization of ANKRD6 is crucial for its function in Wnt signaling
  • involvement of ANKRD6 in processes that are related to the acquisition of cell polarity and require ciliary functions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    player of WNT signaling, with DVL1, in embryogenesis
    a component essential component of the Wnt-signaling pathway and
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with DVL1
  • in the nucleus, interacts with the transcription factor MLLT3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS