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FLASH GENE
Symbol AGTPBP1 contributors: - updated : 13-10-2006
HGNC name ATP/GTP binding protein 1
HGNC id 17258
Corresponding disease
PCDRS Purkinje cell and retinal phosphoreceptors degeneration
Location 9q21.33      Physical location : 88.161.454 - 88.356.944
Synonym name
  • nervous system nuclear protein inducer by axotomy 1
  • KIAA1035 protein
  • Synonym symbol(s) KIAA1035, NNA1
    DNA
    TYPE functioning gene
    STRUCTURE 195.00 kb     27 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrinethyroid   highly
    Lymphoid/Immunelymph node   highly
    Nervousbrain    
    Reproductivemale systemtestis  highly
    Visualeyeretina   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text developing brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one zinc peptide domain
  • nuclear localization signal (NLS)
  • ATP/GTP-binding motif of the P loop type
  • one leucine zipper
  • four consensus phosphoregulation sites for tyrosine kinase
  • HOMOLOGY
    interspecies ortholog to murine Agtpbp1
    intraspecies homolog to AEBP1
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • zinc carboxypeptidase may contribute to nuclear signaling events in differentiating and regenerating neurons
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text involved in axonal regeneration
    PATHWAY
    metabolism
    signaling sensory transduction/vision
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
    zinc Zn2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PCDRS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    mouse Purkinje cell degeneration (pcd)