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FLASH GENE
Symbol AGTPBP1 contributors: - updated : 13-10-2006
HGNC name ATP/GTP binding protein 1
HGNC id 17258
DNA
TYPE functioning gene
STRUCTURE 195.00 kb     27 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Endocrinethyroid   highly
Lymphoid/Immunelymph node   highly
Nervousbrain    
Reproductivemale systemtestis  highly
Visualeyeretina   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral   
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text developing brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one zinc peptide domain
  • nuclear localization signal (NLS)
  • ATP/GTP-binding motif of the P loop type
  • one leucine zipper
  • four consensus phosphoregulation sites for tyrosine kinase
    • HOMOLOGY
    interspecies ortholog to murine Agtpbp1
    intraspecies homolog to AEBP1
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • zinc carboxypeptidase may contribute to nuclear signaling events in differentiating and regenerating neurons
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text involved in axonal regeneration
    PATHWAY
    metabolism
    signaling sensory transduction/vision
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
    zinc Zn2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PCDRS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    mouse Purkinje cell degeneration (pcd)