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FLASH GENE

Symbol

AGTPBP1

contributors: - updated : 13-10-2006

HGNC name	ATP/GTP binding protein 1
HGNC id	17258

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Endocrine thyroid       highly Lymphoid/Immune lymph node       highly Nervous brain         Reproductive male system testis     highly Visual eye retina

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central       Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	developing brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one zinc peptide domain
	nuclear localization signal (NLS)
	ATP/GTP-binding motif of the P loop type
	one leucine zipper
	four consensus phosphoregulation sites for tyrosine kinase

HOMOLOGY

interspecies

ortholog to murine Agtpbp1

intraspecies

homolog to AEBP1

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION

zinc carboxypeptidase may contribute to nuclear signaling events in differentiating and regenerating neurons

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text	involved in axonal regeneration

PATHWAY

metabolism

signaling

sensory transduction/vision

a component

INTERACTION

DNA

RNA

small molecule	metal binding, cofactor,
	zinc Zn2+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

PCDRS

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

mouse Purkinje cell degeneration (pcd)