Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ADRA2B contributors: mct - updated : 24-03-2015
HGNC name adrenergic, alpha-2B-, receptor
HGNC id 282
Corresponding disease
BAFME2 benign adult familial myoclonic epilepsy 2
Location 2q11.1      Physical location : 96.778.625 - 96.781.888
Synonym symbol(s) ADRA2L1, ADRA2RL1, ADRARL1, ALPHA2BAR
DNA
TYPE functioning gene
STRUCTURE 3.37 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC389003 2 LOC389003 PROM2 2q11.1 prominin 2 CSEN 2q11.2-q11.3 calsenilin, presenilin binding protein, EF hand transcription factor CGI-105 2p24.3-p11.2 CGI-105 protein LOC129870 2q11.2 similar to autoantigen NOR-90 LOC389004 2 similar to tripartite motif-containing 43 FLJ14082 2q11.2 hypothetical protein FLJ14082 LOC389005 2 similar to RING finger protein 18 (Testis-specific ring-finger protein) TRIM43 2q11 tripartite motif-containing 43 LOC285031 2q11.2 similar to autoantigen NOR-90 LOC129872 2q11.2 similar to Glycerol-3-phosphate acyltransferase, mitochondrial precursor (GPAT) LOC150759 2q11.2 hypothetical protein LOC150759 LOC389006 2 similar to KIAA1641 protein LOC389007 2 similar to hypothetical protein LOC150763 2q11.2 hypothetical protein LOC150763 ADRA2B 2p13-q13 adrenergic, alpha-2B-, receptor LOC200515 2q11.2 similar to hypothetical protein 7420700F21 DUSP2 2q11 dual specificity phosphatase 2 STARD7 2q11.1 START domain containing 7 FLJ20507 2q11.2 hypothetical protein FLJ20507 CIAO1 2q11.2 hypothetical protein FLJ20507 U5-200KD 2q11.1 hypothetical protein FLJ20507 KIAA1754L 2q11.2 KIAA1754-like BRRN1 2q11.2 barren homolog (Drosophila) LOC93082 2q11.2 hypothetical protein BC012317 MRF-1 FLJ10081 2p12-p11.2 hypothetical protein FLJ10081 LOC391408 2 similar to myoferlin isoform b; fer-1-like 3 LOC90342 2q11.2 similar to fer-1 like protein 3 LMAN2L 2q11.1 lectin, mannose-binding 2-like CNNM4 2p12-p11.2 cyclin M4 LOC130643 2q11.2 hypothetical LOC130643 CNNM3 2p12-p11.2 cyclin M3 DARP MGC41816 2q11.2 hypothetical protein MGC41816
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 3371 - 450 - -
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
seven transmembrane segments (7TM)
conjugated LipoP
HOMOLOGY
interspecies ortholog to rattus Adra2b
ortholog to murine Adra2b
Homologene
FAMILY
  • G protein coupled receptor superfamily
  • G-protein coupled receptor 1 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • integral to plasma membrane
  • basic FUNCTION
  • inhibiting Ca2+ channels
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • a triple arg motif mediates ADRA2B interaction with SEC24C/D and export from the endoplasmic reticulum (ER)
  • directly and activation-dependently interacted with ADRA2B, specifically the third intracellular loop
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) BAFME2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    deletion of region associated with reduced metabolism in obeses
    Susceptibility
  • obesity
  • to idiopathic orthostatic intolerance (IOI)
  • Variant & Polymorphism other
  • beta1Gly49 polymorphism is protective for IOI
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS