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FLASH GENE
Symbol ADRA2B contributors: mct - updated : 24-03-2015
HGNC name adrenergic, alpha-2B-, receptor
HGNC id 282
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 3371 - 450 - -
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
seven transmembrane segments (7TM)
conjugated LipoP
HOMOLOGY
interspecies ortholog to rattus Adra2b
ortholog to murine Adra2b
Homologene
FAMILY
  • G protein coupled receptor superfamily
  • G-protein coupled receptor 1 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • integral to plasma membrane
  • basic FUNCTION
  • inhibiting Ca2+ channels
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • a triple arg motif mediates ADRA2B interaction with SEC24C/D and export from the endoplasmic reticulum (ER)
  • directly and activation-dependently interacted with ADRA2B, specifically the third intracellular loop
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) BAFME2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    deletion of region associated with reduced metabolism in obeses
    Susceptibility
  • obesity
  • to idiopathic orthostatic intolerance (IOI)
  • Variant & Polymorphism other
  • beta1Gly49 polymorphism is protective for IOI
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS