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FLASH GENE
Symbol ADRA2B contributors: mct - updated : 24-03-2015
HGNC name adrenergic, alpha-2B-, receptor
HGNC id 282
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
seven transmembrane segments (7TM)
conjugated LipoP
HOMOLOGY
interspecies ortholog to rattus Adra2b
ortholog to murine Adra2b
Homologene
FAMILY
  • G protein coupled receptor superfamily
  • G-protein coupled receptor 1 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • integral to plasma membrane
  • basic FUNCTION
  • inhibiting Ca2+ channels
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • a triple arg motif mediates ADRA2B interaction with SEC24C/D and export from the endoplasmic reticulum (ER)
  • directly and activation-dependently interacted with ADRA2B, specifically the third intracellular loop
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) BAFME2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    deletion of region associated with reduced metabolism in obeses
    Susceptibility
  • obesity
  • to idiopathic orthostatic intolerance (IOI)
  • Variant & Polymorphism other
  • beta1Gly49 polymorphism is protective for IOI
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS