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FLASH GENE
Symbol ADCYAP1 contributors: mct/npt - updated : 11-06-2008
HGNC name adenylate cyclase activating polypeptide 1 (pituitary)
HGNC id 241
Location 18p11.31      Physical location : 904.943 - 912.171
Synonym name
  • pituitary adenylate cyclase-activating polypeptide
  • PACAP-related peptide
  • Synonym symbol(s) PACAP, MGC12685
    EC.number 4.6.1.1
    DNA
    TYPE functioning gene
    STRUCTURE 7.00 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map see TYMS
    Physical map
    LOC388454 18 LOC388454 LOC260334 18p11 HSA18p11 beta-tubulin 4Q pseudogene IL9RP4 18p11.3 interleukin 9 receptor pseudogene 4 USP14 18p ubiquitin specific protease 14 (tRNA-guanine transglycosylase) THOC1 18p11.32 THO complex 1 COLEC12 18pter-p11.3 collectin sub-family member 12 LOC390821 18 LOC390821 CETN1 18p11.32 centrin, EF-hand protein, 1 CLUL1 18p11.32 clusterin-like 1 (retinal) TYMS 18p11.32 thymidylate synthetase HSRTSBETA 18p11.32 rTS beta protein YES1 18p11.31-p11.22 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 ADCYAP1 18p11.31 adenylate cyclase activating polypeptide 1 (pituitary) LOC388456 18 hypothetical gene supported by BC039671 C18orf2 18p11 chromosome 18 open reading frame 2 LOC390822 18 similar to RIKEN cDNA 4921525H23 FLJ23017 HEC 18p11.31 similar to RIKEN cDNA 4921525H23 LOC388457 18 hypothetical gene supported by BC006008 KIAA0650 18p11.31 hypothetical gene supported by BC006008 EMILIN2 18p11.3 elastin microfibril interfacer 2 LPIN2 18p11.31 lipin 2 LOC390823 18 similar to 60S ribosomal protein L10 (QM protein) (Tumor suppressor QM) (Laminin receptor homolog) MYOM1 18p11.32-p11.31 myomesin 1 (skelemin) 185kDa MRCL3 18p11.31 myosin regulatory light chain MRCL3 MRLC2 18p11.31 myosin regulatory light chain MRLC2 LOC204777 18p11.31 similar to Immunoglobulin lambda-like polypeptide 1 precursor (Immunoglobulin-related 14.1 protein) (Immunoglobulin omega polypeptide) (Lambda 5) (CD179b antigen) TGIF 18p11.3 TGFB-induced factor (TALE family homeobox) LOC390824 18 similar to hypothetical protein BC007436 DLGAP1 18p11.3 discs, large (Drosophila) homolog-associated protein 1 MGC11082 18p11.31 hypothetical protein MGC11082
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 3159 - 176 - Lohoff (2008)
    5 - 3187 - 176 - Lohoff (2008)
    - - -
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland    
    endocrinebraindiencephalonpituitary  
    Endocrinepancreas   highly
    Nervousbraindiencephalonhypothalamus  
    Skin/Tegumentskin    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, pregnancy
    Text pituitary placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    isoforms Precursor for PACAP27 (N terminal 27 AA of PACAP38) and PACAP38 (N terminal, 38 residues)
    HOMOLOGY
    Homologene
    FAMILY
  • glucagon VIP family
  • vasoactive intestinal peptide (VIP)/secretin/glucagon family of peptides
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • pituitary adenylyl cyclase activating polypeptide, acting as a pivotal modulator of glutamatergic regulation of the suprachiasmatic circadian clock
  • regulator of insulin genes of glucose sensing system (GLTI) and hexokinase
  • auto and paracrine function in the peri and post ovulatory events involving acute progesterone production and subsequent luteinization in periovulatory granulosa/lutein cells
  • decreasing neuronal cell death after ischemia by suppressing cytochrome C release by means of BCL2 regulation
  • participates in the processes forming the neuronal laminas in the developing cortex via the intracellular PKA pathway
  • inhibits proliferation of cortical progenitors and promotes neurogenesis
  • affects two different processes of cortical progenitors via the PKA/CREB signaling pathway acting at different times of the cell cycle, providing a novel cue for unveiling the molecular mechanisms underlying the effects of environmental factors on laminar formation during corticogenesis
  • participates in the processes forming the neuronal laminas in the developing cortex via the intracellular PKA pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with IL6 (prevents neuronal cell death after ischemia via a signaling mechanism involving IL6)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS