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FLASH GENE
Symbol ADCYAP1 contributors: mct/npt - updated : 11-06-2008
HGNC name adenylate cyclase activating polypeptide 1 (pituitary)
HGNC id 241
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland    
endocrinebraindiencephalonpituitary  
Endocrinepancreas   highly
Nervousbraindiencephalonhypothalamus  
Skin/Tegumentskin    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, pregnancy
Text pituitary placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
isoforms Precursor for PACAP27 (N terminal 27 AA of PACAP38) and PACAP38 (N terminal, 38 residues)
HOMOLOGY
Homologene
FAMILY
  • glucagon VIP family
  • vasoactive intestinal peptide (VIP)/secretin/glucagon family of peptides
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • pituitary adenylyl cyclase activating polypeptide, acting as a pivotal modulator of glutamatergic regulation of the suprachiasmatic circadian clock
  • regulator of insulin genes of glucose sensing system (GLTI) and hexokinase
  • auto and paracrine function in the peri and post ovulatory events involving acute progesterone production and subsequent luteinization in periovulatory granulosa/lutein cells
  • decreasing neuronal cell death after ischemia by suppressing cytochrome C release by means of BCL2 regulation
  • participates in the processes forming the neuronal laminas in the developing cortex via the intracellular PKA pathway
  • inhibits proliferation of cortical progenitors and promotes neurogenesis
  • affects two different processes of cortical progenitors via the PKA/CREB signaling pathway acting at different times of the cell cycle, providing a novel cue for unveiling the molecular mechanisms underlying the effects of environmental factors on laminar formation during corticogenesis
  • participates in the processes forming the neuronal laminas in the developing cortex via the intracellular PKA pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with IL6 (prevents neuronal cell death after ischemia via a signaling mechanism involving IL6)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS