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FLASH GENE
Symbol ADCYAP1 contributors: mct/npt - updated : 11-06-2008
HGNC name adenylate cyclase activating polypeptide 1 (pituitary)
HGNC id 241
Location 18p11.31      Physical location : 904.943 - 912.171
Synonym name
  • pituitary adenylate cyclase-activating polypeptide
  • PACAP-related peptide
  • Synonym symbol(s) PACAP, MGC12685
    EC.number 4.6.1.1
    DNA
    TYPE functioning gene
    STRUCTURE 7.00 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map see TYMS
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 3159 - 176 - Lohoff (2008)
    5 - 3187 - 176 - Lohoff (2008)
    - - -
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland    
    endocrinebraindiencephalonpituitary  
    Endocrinepancreas   highly
    Nervousbraindiencephalonhypothalamus  
    Skin/Tegumentskin    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, pregnancy
    Text pituitary placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    isoforms Precursor for PACAP27 (N terminal 27 AA of PACAP38) and PACAP38 (N terminal, 38 residues)
    HOMOLOGY
    Homologene
    FAMILY
  • glucagon VIP family
  • vasoactive intestinal peptide (VIP)/secretin/glucagon family of peptides
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • pituitary adenylyl cyclase activating polypeptide, acting as a pivotal modulator of glutamatergic regulation of the suprachiasmatic circadian clock
  • regulator of insulin genes of glucose sensing system (GLTI) and hexokinase
  • auto and paracrine function in the peri and post ovulatory events involving acute progesterone production and subsequent luteinization in periovulatory granulosa/lutein cells
  • decreasing neuronal cell death after ischemia by suppressing cytochrome C release by means of BCL2 regulation
  • participates in the processes forming the neuronal laminas in the developing cortex via the intracellular PKA pathway
  • inhibits proliferation of cortical progenitors and promotes neurogenesis
  • affects two different processes of cortical progenitors via the PKA/CREB signaling pathway acting at different times of the cell cycle, providing a novel cue for unveiling the molecular mechanisms underlying the effects of environmental factors on laminar formation during corticogenesis
  • participates in the processes forming the neuronal laminas in the developing cortex via the intracellular PKA pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with IL6 (prevents neuronal cell death after ischemia via a signaling mechanism involving IL6)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS