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FLASH GENE
Symbol ADCYAP1 contributors: mct/npt - updated : 11-06-2008
HGNC name adenylate cyclase activating polypeptide 1 (pituitary)
HGNC id 241
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
isoforms Precursor for PACAP27 (N terminal 27 AA of PACAP38) and PACAP38 (N terminal, 38 residues)
HOMOLOGY
Homologene
FAMILY
  • glucagon VIP family
  • vasoactive intestinal peptide (VIP)/secretin/glucagon family of peptides
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • pituitary adenylyl cyclase activating polypeptide, acting as a pivotal modulator of glutamatergic regulation of the suprachiasmatic circadian clock
  • regulator of insulin genes of glucose sensing system (GLTI) and hexokinase
  • auto and paracrine function in the peri and post ovulatory events involving acute progesterone production and subsequent luteinization in periovulatory granulosa/lutein cells
  • decreasing neuronal cell death after ischemia by suppressing cytochrome C release by means of BCL2 regulation
  • participates in the processes forming the neuronal laminas in the developing cortex via the intracellular PKA pathway
  • inhibits proliferation of cortical progenitors and promotes neurogenesis
  • affects two different processes of cortical progenitors via the PKA/CREB signaling pathway acting at different times of the cell cycle, providing a novel cue for unveiling the molecular mechanisms underlying the effects of environmental factors on laminar formation during corticogenesis
  • participates in the processes forming the neuronal laminas in the developing cortex via the intracellular PKA pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with IL6 (prevents neuronal cell death after ischemia via a signaling mechanism involving IL6)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS