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FLASH GENE
Symbol CDK5 contributors: mct/pgu/shn - updated : 24-06-2020
HGNC name cyclin-dependent kinase 5
HGNC id 1774
ANIMAL & CELL MODELS
  • Cdk5(-/-) mice exhibit unique lesions in the central nervous system associated with perinatal mortality
  • cdk5-deficient cultured cortical neurons exhibit increased sensitivity to apoptotic stimuli, and elevated JNK3 activity and c-Jun phosphorylation
  • Sema3A-induced growth cone collapse responses were attenuated in cdk5-deficient mice
  • Cdk5 conditional knockout mice with restricted deletion of the Cdk5 gene in specific neurons display neuronal migration defects
  • Cdk5-/- mice display morphological abnormalities at the neuromuscular junction pre- and postsynaptically