| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| constitutional
|
|
| --low
|
| |
in Alzheimer disease (cycling neurons are characterized by a predominantly cytoplasmic distribution of CDK5) | | constitutional
|
|
| --other
|
| |
dysregulation dramatically affects striatal-dependent brain function and may be relevant to non-neurodegenerative disorders involving dopamine neurotransmission | | constitutional
|
|
|
| loss of function
|
results in abnormal development of the nervous system accompanied by massive disruptions in cortical migration and lamination, therefore impacting synaptic activity  | | constitutional
|
|
|
| gain of function
| |
in several neurodegenerative diseases where Golgi disassembly also occurs, this may be a common mechanism among multiple disorders | | constitutional
|
|
| --over
|
| |
significantly increased in AD, leading to nuclear envelope dispersion and contributing to all three hallmarks: neurotoxic amyloid-beta (Abeta), neurofibrillary tangles (NFT), and extensive cell death | |
