basic FUNCTION
| importantfor brain development and neuronal differentiation and may play critical roles in neuronal cytoskeleton structure and organization |
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plays a pivotal role during development of the central nervous system |
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phosphorylates the MAP kinase kinase-1 in vivo as well as the Ras-activated MEK1 in vitro |
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directly phosphorylates c-Jun N-terminal kinase 3 |
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may exert a key role in promoting neuronal survival by regulating Akt activity through the neuregulin/PI 3-kinase signaling pathway |
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has an essential role in synaptic vesicle endocytosis |
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phosphorylates synaptojanin 1 and regulates its function both in vitro and in intact synaptosomes |
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essential role in regulation of the development of motor axons and neuromuscular synapses |
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role in nociception |
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phosphorylates Wiskott-Aldrich syndrome protein (WASP)--family verprolin homologous protein 1, WAVE1 |
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serine/threonine kinase phosphorylating PPP1R1B (dopamine and cAMP regulated phospho protein) |
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modulating dopamine signaling and neurofilament metabolism in axon outgrowth |
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playing a role in regulation of muscular differentiation |
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involved in the regulation of acetylcholine receptor expression at the neuromuscular junction |
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may be involved in the control of the cell cycle |
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by regulating PRDX2 activity, can determine dopaminergic neuron survival, and involved in the brain development |
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facilitates calpain-mediated proteolysis of GRIN2B and may control synaptic plasticity and learning |
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playing a role in the maintenance of a postmitotic state (nuclear CDK5 plays an active role in allowing neurons to remain postmitotic as they mature and loss of nuclear CDK5 leads to cell cycle entry) |
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has an unexpected but widespread role as a negative cell cycle regulator in postmitotic neurons |
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regulates striatal dopamine neurotransmission and behavioral responses to cocaine, modulating the effects of cocaine (including its ability to induce neuro-adaptations in signaling, behavior, and neuronal morphology) |
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directly phosphorylates PPP1R19A and controls its association with F-actin |
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regulate Kalirin function throughout development |
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having an essential role in the survival, but not proliferation, of adult-generated hippocampal neurons through both cell-intrinsic and cell-extrinsic mechanisms |
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involvement of CDK5 in the regulation of insulin-dependent glucose uptake in adipocytes |
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regulates neurogenesis through both intrinsic and extrinsic mechanisms in the subgranular zone of the adult hippocampus |
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phosphorylates the talin head and inhibits its interaction with SMURF1 and its degradation |
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displays kinase activity predominantly in postmitotic neurons, and plays a central role in the morphology change of senescent cells |
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regulates cellular processes such as cell-cell and cell-matrix adhesion, cell migration and wound healing in a variety of tissues |
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implicated in the signaling pathways that regulate cell adhesion and migration of variety of cell types |
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regulates synaptic plasticity, controls neuronal and behavioral stimulus-induced excitability and may be a novel pharmacological target for cognitive and anticonvulsant therapies |
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CDK1, CDK2, CDK5, can phosphorylate human DNMT1 at Ser154, suggesting an important role for CDKs in controlling DNA methylation patterns in mammalian cells |
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implicated in a new regulatory mechanism of axon formation through CDK5-dependent phosphorylation of Axin ( |
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activators of CDK5, CDK5R1, and CCNI are not required for normal kidney function, but, they play pivotal coordinated roles in maintaining podocyte survival during stress states in disease |
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a role for during the progression of a normal cell cycle |
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is a brain-specific membrane-bound protein kinase that is activated by binding to CDK5R1, CDK5R2 |
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CDK5 regulates SOX6 steady state protein level that has an important role in brain development and function) |
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CDK5/CDK5R1 regulates spatial learning and memory, implicating CDK5/CDK5R1 as a therapeutic target in neurological disorders |
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subcellular localization of CDK5 is determined by its specific activators |
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plays an important role in neurotransmission and synaptic plasticity in the normal function of the adult brain, and dysregulation can lead to Tau hyperphosphorylation and cognitive impairment |
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CDK5 and CDK5R1, encoding CDK5 activator p35, have a fundamental role in central nervous system (CNS) development and function, and are involved in the pathogenesis of several neurodegenerative disorders |
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CDK5 and FIBP have a proven essential role in cell division |
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CDK5, YWHAE, and CDK5 cofactor C2CD5 together promote NDEL1 phosphorylation and are essential for force adaptation |