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FLASH GENE
Symbol BRD2 contributors: mct - updated : 23-10-2019
HGNC name bromodomain containing 2
HGNC id 1103
ANIMAL & CELL MODELS
  • disruption of Brd2, an unusual MHC gene, causes lifelong severe obesity in mice with pancreatic islet expansion, hyperinsulinaemia, hepatosteatosis and elevated pro-inflammatory cytokines, but, surprisingly, enhanced glucose tolerance, elevated adiponectin, increased weight of brown adipose tissue
  • viable Brd2(+/-) heterozygotes mice show both decreased GABAergic neuron counts and increased susceptibility to seizures