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FLASH GENE

Symbol

BRD2

contributors: mct - updated : 23-10-2019

HGNC name	bromodomain containing 2
HGNC id	1103

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

EJM3

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in certain types of leukemia

Susceptibility

to juvenile myoclonic epilepsy

Variant & Polymorphism SNP , other	polymorphisms confering increased risk of juvenile myoclonic epilepsy

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     inhibition of the BET-histone interaction results in transcriptional downregulation of a number of oncogenes, providing a novel pharmacologic strategy for the treatment of cancer

ANIMAL & CELL MODELS

	disruption of Brd2, an unusual MHC gene, causes lifelong severe obesity in mice with pancreatic islet expansion, hyperinsulinaemia, hepatosteatosis and elevated pro-inflammatory cytokines, but, surprisingly, enhanced glucose tolerance, elevated adiponectin, increased weight of brown adipose tissue
	viable Brd2(+/-) heterozygotes mice show both decreased GABAergic neuron counts and increased susceptibility to seizures