basic FUNCTION
| protein serine/threonine kinase, identified by the monoclonal antibody LY9, overexpressed in proliferating endothelial cells |
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mitogen-activated kinase |
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translocating in the nucleus the promoter of a number of the E2 family of transcription factors |
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playing a role in regulating brain development |
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having distinct roles in initiating apoptosis, and the dotted distribution pattern in nucleus may be a morphologic marker of cell apoptosis |
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TBP-associated protein recruiting TBP into E2F1 transcriptional complex in response to serum stimulation |
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has intrinsic histone chaperone activity and is required for transcription of the cyclin D1 gene |
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required for the completion of embryogenesis and proper neural tube closure during development |
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transcriptional co-activator/co-repressor with SWI/SNF (switch mating type/sucrose non-fermenting)-like functions that regulates chromatin |
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BET family members have been recognized as essential genes for the replication of viruses and in mediating inflammatory responses |
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BET family proteins recognize acetylated chromatin through their two bromodomains, acting as transcriptional activators or tethering viral genomes to the mitotic chromosomes of their host |
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BRD2 is likely required for cell cycle exit and neuronal differentiation of neuroepithelial cells through the E2F1 pathway during CNS development |
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BRD2, BRD3, BRD4, and BRDT are transcriptional regulators required for efficient expression of several growth promoting and antiapoptotic genes as well as for cell-cycle progression |
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transcriptional coregulator, that couples chromatin to cell-cycle progression |
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plays a critical, independent role in regulation of mitogenic response genes, particularly cyclin A, in B cells |
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suppresses adipocyte differentiation |
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antagonistic relationship between H2AZ1 monoubiquitylated and BRD2 to regulate the transcriptional balance at bivalent genes to enable proper execution of developmental programs |
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separate and interdependent BRD2 and BRD4 functions in potentiating the genetic program required for Th17 cell development and adaptive immunity |
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BRD2 therefore creates a restricted chromatin environment surrounding DSBs which facilitates DSB repair and which is framed by extensive ZMYND8 domains on the flanking chromatin |