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FLASH GENE

Symbol

CBX7

contributors: mct - updated : 17-05-2023

HGNC name	chromobox homolog 7
HGNC id	1557

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in prostate tumor cells tumoral     --over   in follicular lymphoma tumoral     --low   drastically down-regulated in six thyroid carcinoma cell lines tumoral     --low   loss of CBX7 expression correlates with a highly malignant phenotype in thyroid cancer patients tumoral     --over   in gastric cancer cell lines and gastric tumors tumoral     --low   significantly downregulated in pancreatic ductal adenocarcinoma, compared to normal pancreatic tissues constitutional       loss of function plays a positive role in dentin and alveolar bone formation tumoral     --low   loss of CBX7 expression might play a critical role in advanced stages of carcinogenesis by deregulating the expression of specific effector genes

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	CBX7 might serve as a promising biomarker in Lung adenocarcinoma (LUAD)
	important prognostic factor, whose loss of expression in general indicates a bad prognosis and a progression towards a fully malignant phenotype
Therapy target
	System Type Disorder Pubmed cancer hemopathy   target for control of follicular lymphoma in the clinic cancer lung   CBX7 might serve aspotential molecular target in Lung adenocarcinoma (LUAD)

ANIMAL & CELL MODELS

Cbx7-knockout mice had a higher fat tissue mass than wild-type, suggesting a role of CBX7 in adipogenesis