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FLASH GENE
Symbol CBX7 contributors: mct - updated : 17-05-2023
HGNC name chromobox homolog 7
HGNC id 1557
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousnervecranial nerve  highly
Visualeye   highly
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticprogenitor cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a chromatin organization modifier (chromo) domain conserved
  • chromobox regions dispensable for chromatin association
    • HOMOLOGY
    interspecies homolog to Drosophila polycomb-like (PcG) chromobox 7 and HP1b
    ortholog to murine Cbx7
    Homologene
    FAMILY
  • polycomb group proteins family
    • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in the compaction of chromatin
  • controls the growth of normal and tumor-derived prostate cells by repressing the CDKN2A
  • chromobox protein causally linked to cancer development and may help explain the low frequency of CDKN2A mutations observed in human follicular lymphoma
  • acts as an oncogene in the carcinogenesis and progression of gastric cancer
  • may regulate tumorigenesis, cell migration and cancer metastasis partially via CDKN2A regulatory pathway
  • within the polycomb repressive complex 1 binds to CDKN2BAS and both CBX7 and CDKN2BAS are found at elevated levels in prostate cancer tissues
  • necessary for recruitment of RNF2 to chromatin, whereas RYBP enhances the PRC1 enzymatic activity
  • negative role of CBX7 in the control of adipocyte cell growth and differentiation
  • is a polycomb protein that participates in the formation of polycomb repressive complex 1
  • critical role of CBX7 in cancer progression
  • transcriptional repressor involved in the regulation of cell proliferation and senescence
  • negatively regulates the proliferation, viability, chemoresistance, and migration of pancreatic cancer cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the Polycomb repressive complex 1 (PRC1) that extends the lifespan of cultured epithelial cells
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • correlation between CBX7 and E-cadherin (CDH1) expression in thyroid carcinomas
  • NR2E1 binds at the CBX7 promoter, inducing its expression
  • CBX7 is an important tumor suppressor that negatively modulates PTEN/Akt signaling during pancreatic tumorigenesis
  • GATA4 and SOX11 are functional downstream targets of CBX7 in controlling axon regeneration
  • interaction between CBX7 and PRMT1, and this interaction is crucial for PRMT1 enzymatic activity both and for the regulation of CDH1 expression, an important hallmark of epithelial-mesenchymal transition (EMT)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate tumor cells
    tumoral     --over  
    in follicular lymphoma
    tumoral     --low  
    drastically down-regulated in six thyroid carcinoma cell lines
    tumoral     --low  
    loss of CBX7 expression correlates with a highly malignant phenotype in thyroid cancer patients
    tumoral     --over  
    in gastric cancer cell lines and gastric tumors
    tumoral     --low  
    significantly downregulated in pancreatic ductal adenocarcinoma, compared to normal pancreatic tissues
    constitutional       loss of function
    plays a positive role in dentin and alveolar bone formation
    tumoral     --low  
    loss of CBX7 expression might play a critical role in advanced stages of carcinogenesis by deregulating the expression of specific effector genes
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • CBX7 might serve as a promising biomarker in Lung adenocarcinoma (LUAD)
  • important prognostic factor, whose loss of expression in general indicates a bad prognosis and a progression towards a fully malignant phenotype
    • Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    target for control of follicular lymphoma in the clinic
    cancerlung 
    CBX7 might serve aspotential molecular target in Lung adenocarcinoma (LUAD)
    ANIMAL & CELL MODELS
  • Cbx7-knockout mice had a higher fat tissue mass than wild-type, suggesting a role of CBX7 in adipogenesis