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FLASH GENE
Symbol CBX7 contributors: mct - updated : 17-05-2023
HGNC name chromobox homolog 7
HGNC id 1557
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 3964 - 251 - 2007 17374722
6 - 3832 - 158 - 2007 17374722
6 - 4108 - 158 - 2007 17374722
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousnervecranial nerve  highly
Visualeye   highly
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticprogenitor cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a chromatin organization modifier (chromo) domain conserved
  • chromobox regions dispensable for chromatin association
  • HOMOLOGY
    interspecies homolog to Drosophila polycomb-like (PcG) chromobox 7 and HP1b
    ortholog to murine Cbx7
    Homologene
    FAMILY
  • polycomb group proteins family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in the compaction of chromatin
  • controls the growth of normal and tumor-derived prostate cells by repressing the CDKN2A
  • chromobox protein causally linked to cancer development and may help explain the low frequency of CDKN2A mutations observed in human follicular lymphoma
  • acts as an oncogene in the carcinogenesis and progression of gastric cancer
  • may regulate tumorigenesis, cell migration and cancer metastasis partially via CDKN2A regulatory pathway
  • within the polycomb repressive complex 1 binds to CDKN2BAS and both CBX7 and CDKN2BAS are found at elevated levels in prostate cancer tissues
  • necessary for recruitment of RNF2 to chromatin, whereas RYBP enhances the PRC1 enzymatic activity
  • negative role of CBX7 in the control of adipocyte cell growth and differentiation
  • is a polycomb protein that participates in the formation of polycomb repressive complex 1
  • critical role of CBX7 in cancer progression
  • transcriptional repressor involved in the regulation of cell proliferation and senescence
  • negatively regulates the proliferation, viability, chemoresistance, and migration of pancreatic cancer cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the Polycomb repressive complex 1 (PRC1) that extends the lifespan of cultured epithelial cells
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • correlation between CBX7 and E-cadherin (CDH1) expression in thyroid carcinomas
  • NR2E1 binds at the CBX7 promoter, inducing its expression
  • CBX7 is an important tumor suppressor that negatively modulates PTEN/Akt signaling during pancreatic tumorigenesis
  • GATA4 and SOX11 are functional downstream targets of CBX7 in controlling axon regeneration
  • interaction between CBX7 and PRMT1, and this interaction is crucial for PRMT1 enzymatic activity both and for the regulation of CDH1 expression, an important hallmark of epithelial-mesenchymal transition (EMT)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate tumor cells
    tumoral     --over  
    in follicular lymphoma
    tumoral     --low  
    drastically down-regulated in six thyroid carcinoma cell lines
    tumoral     --low  
    loss of CBX7 expression correlates with a highly malignant phenotype in thyroid cancer patients
    tumoral     --over  
    in gastric cancer cell lines and gastric tumors
    tumoral     --low  
    significantly downregulated in pancreatic ductal adenocarcinoma, compared to normal pancreatic tissues
    constitutional       loss of function
    plays a positive role in dentin and alveolar bone formation
    tumoral     --low  
    loss of CBX7 expression might play a critical role in advanced stages of carcinogenesis by deregulating the expression of specific effector genes
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • CBX7 might serve as a promising biomarker in Lung adenocarcinoma (LUAD)
  • important prognostic factor, whose loss of expression in general indicates a bad prognosis and a progression towards a fully malignant phenotype
  • Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    target for control of follicular lymphoma in the clinic
    cancerlung 
    CBX7 might serve aspotential molecular target in Lung adenocarcinoma (LUAD)
    ANIMAL & CELL MODELS
  • Cbx7-knockout mice had a higher fat tissue mass than wild-type, suggesting a role of CBX7 in adipogenesis