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FLASH GENE

Symbol

CYSLTR1

contributors: mct - updated : 28/11/2008

HGNC name	cysteinyl leukotriene receptor 1
HGNC id	17451

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       gain of function in a bronchial epithelial cell line leads to signal transducer and activator of transcription 1-mediated eosinophil adhesion

Susceptibility

to aspirin-intolerant asthma (AIA)

Variant & Polymorphism other	polymorphism contributing to develop to the AIA phenotype and used as a genetic marker for differentiating two major aspirin hypersensitivity phenotypes

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed allergy asthm   CysLT(1)R antagonism may contribute to the control of the chronic inflammatory condition that characterizes airways in asthma

ANIMAL & CELL MODELS