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FLASH GENE

Symbol

CYSLTR1

contributors: mct - updated : 28/11/2008

HGNC name	cysteinyl leukotriene receptor 1
HGNC id	17451

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven transmembrane segments (7TM) receptor

HOMOLOGY

Homologene

FAMILY	G protein coupled receptor superfamily
	cysteinyl leukotriene receptor family

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	cysteinyl leukotrienes (C4,D4,E4) receptor 1
	signaling through elevation of intracellular calcium
	can significantly influence the activation and migration of monocytes
	may contribute to develop to the aspirin-intolerant asthma phenotype and be used as a genetic marker for differentiating two major aspirin hypersensitivity phenotypes

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense , respiration

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

activated by

leukotrienes C4,D4,E4

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       gain of function in a bronchial epithelial cell line leads to signal transducer and activator of transcription 1-mediated eosinophil adhesion

Susceptibility

to aspirin-intolerant asthma (AIA)

Variant & Polymorphism other	polymorphism contributing to develop to the AIA phenotype and used as a genetic marker for differentiating two major aspirin hypersensitivity phenotypes

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed allergy asthm   CysLT(1)R antagonism may contribute to the control of the chronic inflammatory condition that characterizes airways in asthma

ANIMAL & CELL MODELS