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FLASH GENE

Symbol

CYSLTR1

contributors: mct - updated : 28/11/2008

HGNC name	cysteinyl leukotriene receptor 1
HGNC id	17451

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	Xq21.1      Physical location : 77.528.130 - 77.583.087
Synonym name	cysteinyl leukotrienes (C4,D4,E4) receptor 1
	LTD4 receptor
Synonym symbol(s)	CST1P, CysLT1, CysLT(1), CYSLT1R, HG55, HMTMF81, MGC46139

DNA

TYPE	functioning gene
STRUCTURE	54.96 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006639 3 - 1537 NP_006630 38 337 - 2008 18305014

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive pharynx         Lymphoid/Immune lymph node         Respiratory lung           respiratory tract trachea

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte Lymphoid/Immune macrophage

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven transmembrane segments (7TM) receptor

HOMOLOGY

Homologene

FAMILY	G protein coupled receptor superfamily
	cysteinyl leukotriene receptor family

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	cysteinyl leukotrienes (C4,D4,E4) receptor 1
	signaling through elevation of intracellular calcium
	can significantly influence the activation and migration of monocytes
	may contribute to develop to the aspirin-intolerant asthma phenotype and be used as a genetic marker for differentiating two major aspirin hypersensitivity phenotypes

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense , respiration

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

activated by

leukotrienes C4,D4,E4

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       gain of function in a bronchial epithelial cell line leads to signal transducer and activator of transcription 1-mediated eosinophil adhesion

Susceptibility

to aspirin-intolerant asthma (AIA)

Variant & Polymorphism other	polymorphism contributing to develop to the AIA phenotype and used as a genetic marker for differentiating two major aspirin hypersensitivity phenotypes

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed allergy asthm   CysLT(1)R antagonism may contribute to the control of the chronic inflammatory condition that characterizes airways in asthma

ANIMAL & CELL MODELS