Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

PML

contributors: shn - updated : 21-05-2016

HGNC name	promyelocytic leukemia
HGNC id	9113

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

PML

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral germinal mutation       mutated in acute promyelocytic leukemia with associates with poor prognosis and RA unresponsiveness tumoral fusion       fused with RARA int (15;17) in acute promyelocytic leukemia

Susceptibility

to Paget disease (PDB)

Variant & Polymorphism other	rs5742915 strongly associated with PDB

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     PML-RARA degradation or therapy-triggered degradation of oncoproteins could be a general strategy to eradicate cancer stem cells

ANIMAL & CELL MODELS

	PMLRAR alpha transgenic mice exhibited neutrophil differentiation impairment and acute promyelocytic leukemia
	Pml–/– mice had smaller brains and hippocampus than Pml+/+ and Pml+/– mice although the overall organization of the brain did not appear to be affected
	PML-RARA-targeted DNA vaccine induces protective immunity in a mouse model of leukemia