Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

IL4R

contributors: mct - updated : 29-11-2012

HGNC name	interleukin 4 receptor
HGNC id	6015

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --other   aberrantly expressed in malignant pleural mesothelioma (MPM), and is associated with poor survival and promotion of tumor inflammation

Susceptibility

susceptibility to atopy asthma and immune hyper IgE syndrome susceptibility to osteoarthritis to type 1 diabetes

Variant & Polymorphism SNP , other	with a polymorphism associated with increased signaling
	SNP predisposing to osteoarthritis in Caucasian females
	association of SNPs in IL4R with T1D

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer lung   IL-4/IL4R axis is a potential therapeutic target in malignant pleural mesothelioma cancer digestive colon therapeutic targeting of IL4R in colon cancer

ANIMAL & CELL MODELS