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FLASH GENE

Symbol

IL4R

contributors: mct - updated : 29-11-2012

HGNC name	interleukin 4 receptor
HGNC id	6015

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an extracellular cytokine receptor-like domain containing four conserved residues and a double conserved tryptophan serine motif
	cysteine residues
	a conserved WSXWS motif
	one fibronectin type III domain
	an immunoreceptor tyrosine-based inhibitory motif (ITIM) centered on tyrosine 709 (Y709) in the cytoplasmic domain that binds a number of regulatory phosphatases

conjugated

GlycoP

mono polymer

heteromer , dimer

HOMOLOGY

interspecies	ortholog to murine Il4ra
	ortholog to C.elegans f45e12.2

Homologene

FAMILY

type I cytokine family of receptors,subfamily 4

CATEGORY

immunity/defense , signaling cytokine , receptor membrane serine/threonine

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
text	localized proximal to the transmembrane region
	type I membrane protein

basic FUNCTION	may represent a regulatory molecule specific for IL4-dependent immune responses
	promotes airway hyperresponsiveness through multiple mechanisms
	IL13 and IL4R may play an important role in the etiology of renal cell carcinoma
	may play certain roles in the lipid metabolism, suggesting a novel link between lipid metabolism and the cytokine receptor
	IL4 and IL4 receptor expression is dispensable for the development and function of natural killer T cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

inflammation

PATHWAY

metabolism

signaling

signal transduction

a component

component of the receptor complex for the T helper 2 cytokines IL4 and IL13

INTERACTION

DNA

RNA

small molecule

protein	common gamma chain (IL2RG)
	DOCK2 links T cell receptor signals to downregulation of IL4R to control the lineage commitment of CD4+ T cells
	association of SYK to IL4R is of biological significance and IL4R is a new candidate to be added to the few cytokine receptor components which associate with SYK
	IL4 exerts its proliferative actions via IL4R in hepatocytes, and eosinophil-derived IL4 stimulates hepatocyte proliferation in regenerating liver

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --other   aberrantly expressed in malignant pleural mesothelioma (MPM), and is associated with poor survival and promotion of tumor inflammation

Susceptibility

susceptibility to atopy asthma and immune hyper IgE syndrome susceptibility to osteoarthritis to type 1 diabetes

Variant & Polymorphism SNP , other	with a polymorphism associated with increased signaling
	SNP predisposing to osteoarthritis in Caucasian females
	association of SNPs in IL4R with T1D

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer lung   IL-4/IL4R axis is a potential therapeutic target in malignant pleural mesothelioma cancer digestive colon therapeutic targeting of IL4R in colon cancer

ANIMAL & CELL MODELS