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FLASH GENE
Symbol IL4R contributors: mct - updated : 29-11-2012
HGNC name interleukin 4 receptor
HGNC id 6015
DNA
TYPE functioning gene
STRUCTURE 50.87 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Binding site
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 3710 - 825 - 2007 17767160
11 - 3821 - 810 - 2007 17767160
10 - 3577 - 825 - 2007 17767160
10 - 3589 - 665 - 2007 17767160
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   highly
Reproductivemale systemprostate  moderately
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneT cell
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an extracellular cytokine receptor-like domain containing four conserved residues and a double conserved tryptophan serine motif
  • cysteine residues
  • a conserved WSXWS motif
  • one fibronectin type III domain
  • an immunoreceptor tyrosine-based inhibitory motif (ITIM) centered on tyrosine 709 (Y709) in the cytoplasmic domain that binds a number of regulatory phosphatases
  • conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies ortholog to murine Il4ra
    ortholog to C.elegans f45e12.2
    Homologene
    FAMILY type I cytokine family of receptors,subfamily 4
    CATEGORY immunity/defense , signaling cytokine , receptor membrane serine/threonine
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text
  • localized proximal to the transmembrane region
  • type I membrane protein
  • basic FUNCTION
  • may represent a regulatory molecule specific for IL4-dependent immune responses
  • promotes airway hyperresponsiveness through multiple mechanisms
  • IL13 and IL4R may play an important role in the etiology of renal cell carcinoma
  • may play certain roles in the lipid metabolism, suggesting a novel link between lipid metabolism and the cytokine receptor
  • IL4 and IL4 receptor expression is dispensable for the development and function of natural killer T cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • component of the receptor complex for the T helper 2 cytokines IL4 and IL13
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • common gamma chain (IL2RG)
  • DOCK2 links T cell receptor signals to downregulation of IL4R to control the lineage commitment of CD4+ T cells
  • association of SYK to IL4R is of biological significance and IL4R is a new candidate to be added to the few cytokine receptor components which associate with SYK
  • IL4 exerts its proliferative actions via IL4R in hepatocytes, and eosinophil-derived IL4 stimulates hepatocyte proliferation in regenerating liver
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    aberrantly expressed in malignant pleural mesothelioma (MPM), and is associated with poor survival and promotion of tumor inflammation
    Susceptibility
  • susceptibility to atopy asthma and immune hyper IgE syndrome
  • susceptibility to osteoarthritis
  • to type 1 diabetes
  • Variant & Polymorphism SNP , other
  • with a polymorphism associated with increased signaling
  • SNP predisposing to osteoarthritis in Caucasian females
  • association of SNPs in IL4R with T1D
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    IL-4/IL4R axis is a potential therapeutic target in malignant pleural mesothelioma
    cancerdigestivecolon
    therapeutic targeting of IL4R in colon cancer
    ANIMAL & CELL MODELS