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FLASH GENE

Symbol

STYK1

contributors: mct/npt - updated : 20-01-2016

HGNC name	serine/threonine/tyrosine kinase 1
HGNC id	18889

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       gain of function in ESR1-negative ESR2- positive breast cancer cells following estrogen treatment (Kimbro 2008) tumoral     --over   in acute leukemia (Kondoh (2009) tumoral     --other   expressed in ovarian cancer and is regulated by estrogen through a GPR30 hormone-signaling pathway, to the exclusion of ESR1 (Jackson 2009)

Susceptibility

Variant & Polymorphism

Candidate gene	STYK1 mRNA might be an ideal target to support the diagnosis of breast cancer especially in tiny tumors in which the malignancy cannot be confirmed by other means (Moriai 2006)
Marker	is a novel drug resistance factor and could be a predictor of the therapeutic response in acute leukemia
Therapy target	in the patients with acute leukemia, inhibition of this molecule could potentially serve as a novel therapeutic target (Kondoh 23009)

ANIMAL & CELL MODELS