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FLASH GENE
Symbol STYK1 contributors: mct/npt - updated : 20-01-2016
HGNC name serine/threonine/tyrosine kinase 1
HGNC id 18889
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one SH2 domain
  • one SH3 domain
  • a putative single transmembrane domain, essential for its localisation
  • a conserved intracellular tyrosine kinase domain that shares homology with members of the platelet-derived growth factor/fibroblast growth factor receptor superfamily (Liu 2004)
    • HOMOLOGY
    Homologene
    FAMILY
  • TYR protein kinase family, RTK family
  • ABLl subfamily
    • CATEGORY protooncogene , receptor membrane kinase
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endosome
    text
  • exclusively located in the cytoplasm (Liu 2004)
  • localisation in early endosomes, and colocalised with epidermal growth factor receptor (EGFR) in activated endosomal vesicles
    • basic FUNCTION
  • involved in protein amino acid phosphorylation
  • oncogene with the capacity of promoting cell transformation, tumorigenesis, and metastasis (Liu 2004)
  • has a strong tendency towards forming aggregates, which may have physiological implications suggesting that this novel receptor kinase is colocalised with EGFR in endosomes to participate in a post-internalisation step of EGFR
  • plays a potential role at the early endosome to late endosome/lysosome sorting step of EGFR
  • atypical receptor protein tyrosine kinase with potent oncogenic potential
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component part of functional molecular complex formed by STYK1, AKT1 and GSK3B that may relay a STYK1-directed tumourigenic cascade
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • mainly plays a role in facilitating the trafficking of EGFR from early endosomes to later endosomes/lysosomes
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    in ESR1-negative ESR2- positive breast cancer cells following estrogen treatment (Kimbro 2008)
    tumoral     --over  
    in acute leukemia (Kondoh (2009)
    tumoral     --other  
    expressed in ovarian cancer and is regulated by estrogen through a GPR30 hormone-signaling pathway, to the exclusion of ESR1 (Jackson 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • STYK1 mRNA might be an ideal target to support the diagnosis of breast cancer especially in tiny tumors in which the malignancy cannot be confirmed by other means (Moriai 2006)
    • Marker
  • is a novel drug resistance factor and could be a predictor of the therapeutic response in acute leukemia
    • Therapy target in the patients with acute leukemia, inhibition of this molecule could potentially serve as a novel therapeutic target (Kondoh 23009)
    ANIMAL & CELL MODELS