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FLASH GENE
Symbol STYK1 contributors: mct/npt - updated : 20-01-2016
HGNC name serine/threonine/tyrosine kinase 1
HGNC id 18889
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 3022 - 422 - 2004 15150103
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousgangliasensory gangliadorsal root  
Reproductivemale systemprostate  predominantly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one SH2 domain
  • one SH3 domain
  • a putative single transmembrane domain, essential for its localisation
  • a conserved intracellular tyrosine kinase domain that shares homology with members of the platelet-derived growth factor/fibroblast growth factor receptor superfamily (Liu 2004)
    • HOMOLOGY
    Homologene
    FAMILY
  • TYR protein kinase family, RTK family
  • ABLl subfamily
    • CATEGORY protooncogene , receptor membrane kinase
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endosome
    text
  • exclusively located in the cytoplasm (Liu 2004)
  • localisation in early endosomes, and colocalised with epidermal growth factor receptor (EGFR) in activated endosomal vesicles
    • basic FUNCTION
  • involved in protein amino acid phosphorylation
  • oncogene with the capacity of promoting cell transformation, tumorigenesis, and metastasis (Liu 2004)
  • has a strong tendency towards forming aggregates, which may have physiological implications suggesting that this novel receptor kinase is colocalised with EGFR in endosomes to participate in a post-internalisation step of EGFR
  • plays a potential role at the early endosome to late endosome/lysosome sorting step of EGFR
  • atypical receptor protein tyrosine kinase with potent oncogenic potential
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component part of functional molecular complex formed by STYK1, AKT1 and GSK3B that may relay a STYK1-directed tumourigenic cascade
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • mainly plays a role in facilitating the trafficking of EGFR from early endosomes to later endosomes/lysosomes
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    in ESR1-negative ESR2- positive breast cancer cells following estrogen treatment (Kimbro 2008)
    tumoral     --over  
    in acute leukemia (Kondoh (2009)
    tumoral     --other  
    expressed in ovarian cancer and is regulated by estrogen through a GPR30 hormone-signaling pathway, to the exclusion of ESR1 (Jackson 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • STYK1 mRNA might be an ideal target to support the diagnosis of breast cancer especially in tiny tumors in which the malignancy cannot be confirmed by other means (Moriai 2006)
    • Marker
  • is a novel drug resistance factor and could be a predictor of the therapeutic response in acute leukemia
    • Therapy target in the patients with acute leukemia, inhibition of this molecule could potentially serve as a novel therapeutic target (Kondoh 23009)
    ANIMAL & CELL MODELS