Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PANX1 contributors: mct - updated : 23-10-2015
HGNC name pannexin 1
HGNC id 8599
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
during melanoma tumor progression
constitutional     --over  
in obese humans PANX1 expression in adipose tissue is increased and correlates with the degree of insulin resistance
constitutional       loss of function
can reduce ATP release and endocochlear potential (EP) generation in the cochlea inducing hearing loss
constitutional       gain of function
PANX1 up-regulation contributes to the development of neuropathic pain and stimulation of inflammasome signaling
constitutional     --over  
expression was significantly higher in the temporal lobe cortex of the patients with temporal lobe epilepsy (TLE) than in the controls
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
neurologyacquired 
inhibition of PX2R7 and PANX1 may be therapeutic in spinal cord inflammation
cancerskin 
may be a viable target for the treatment of melanoma
ANIMAL & CELL MODELS