Symbol
| PANX1
| contributors: mct - updated : 23-10-2015
|
HGNC name
| pannexin 1
|
HGNC id
| 8599
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
|  
| --over
|  
|
during melanoma tumor progression | constitutional
|  
|  
| --over
|  
|
in obese humans PANX1 expression in adipose tissue is increased and correlates with the degree of insulin resistance | constitutional
|  
|  
|  
| loss of function
|
can reduce ATP release and endocochlear potential (EP) generation in the cochlea inducing hearing loss | constitutional
|  
|  
|  
| gain of function
|
PANX1 up-regulation contributes to the development of neuropathic pain and stimulation of inflammasome signaling | constitutional
|  
|  
| --over
|  
|
expression was significantly higher in the temporal lobe cortex of the patients with temporal lobe epilepsy (TLE) than in the controls | |
Variant & Polymorphism
|
| |
Candidate gene
Marker
Therapy target
|
System | Type | Disorder | Pubmed |
neurology | acquired | | |
inhibition of PX2R7 and PANX1 may be therapeutic in spinal cord inflammation | cancer | skin | | |
may be a viable target for the treatment of melanoma |
| | | |