basic FUNCTION
| being a structural component of the GAP junction |
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contributing to electrical communication in the nervous system |
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may be involved in both initiation and propagation of calcium waves |
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contribute to the electrical and metabolic coupling, or to signaling between retinal neurons via the secondary messengers |
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capable of forming communicating junctions but also proved to be active in forming of unopposed hemichannels |
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may function in neurons as non-junctional channels (pannexons) at postsynaptic sites and comprises a novel component of the postsynaptic protein complex |
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with PANX3 have many characteristics that are distinct from GJA1 and these proteins probably play an important biological role as single membrane channels |
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play a role in gap junctional intercellular communication and as single-membrane channels, although many of its molecular characteristics differ from connexins (important role for pannexin glycosylation in trafficking) |
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has kinetics and dynamics that make it unique to serve distinct functions separate from connexin-based channels |
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activates the inflammasome in neurons and astrocytes |
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like connexins, may play an important role in hearing |
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PANX1 hemichannels and P2RX1 and P2RX4 facilitate ATP release and autocrine feedback mechanisms that control Ca(2+) entry and T-cell activation at the immune synapse |
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mediator of find-me signal/nucleotide release from apoptotic cells |
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plasma membrane channel mediating the regulated release of find-me signals and selective plasma membrane permeability during apoptosis, with a new mechanism of activation by caspases |
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implicated in ATP-mediated auto-/paracrine signaling, and having a crucial role potential in several cell death pathways |
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constitutes the large conductance cation channel of cardiac myocytes, and PANX1 channels potentially promote arrhythmogenic activities |
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not only facilitates growth of the primary tumor but further enhances the ability of tumor cells to metastasize |
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PANX1 channels in the kidney may regulate ATP release and via purinergic signaling may participate in the control of renal epithelial fluid and electrolyte transport and vascular functions |
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ATP release through PANX1 channels plays a critical role in maintaining synaptic strength and plasticity in CA1 neurons of the adult hippocampus |
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PANX1 channels may play an important role in mediating gut function and in inflammatory bowel diseases (IBD) pathophysiology |
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controls cellular properties of keratinocytes and dermal fibroblasts during early stages of skin development and modulates wound repair upon injury |
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PANX1 and PANX3 are co-expressed in human skeletal muscle myoblasts and play a pivotal role in dictating the proliferation and differentiation status of these cells |
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is a large-pore membrane channel involved in the release of ATP and other signaling mediators (pMID: 25925949) |
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gap junction gene in vertebrates whose proteins mainly function as non-junctional channels on the cell surface |
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is involved in chronic pain signaling by interacting with NMDAR in neurons and with P2RX7 in glia |
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role for PANX1 channels in promoting leukocyte adhesion and emigration through the venous wall during acute systemic inflammation |
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PANX1 channel activity regulates insulin-stimulated glucose uptake in adipocytes and thus contributes to control of metabolic homeostasis |
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NXF2 and its co-factor, NXT1, form a complex with PANX1 and are required for co-transcriptional silencing of transposons in somatic and germline cells of the ovary |