| basic FUNCTION
| being a structural component of the GAP junction |
|
contributing to electrical communication in the nervous system |
|
may be involved in both initiation and propagation of calcium waves |
|
contribute to the electrical and metabolic coupling, or to signaling between retinal neurons via the secondary messengers  |
|
capable of forming communicating junctions but also proved to be active in forming of unopposed hemichannels |
|
may function in neurons as non-junctional channels (pannexons) at postsynaptic sites and comprises a novel component of the postsynaptic protein complex |
|
with PANX3 have many characteristics that are distinct from GJA1 and these proteins probably play an important biological role as single membrane channels |
|
play a role in gap junctional intercellular communication and as single-membrane channels, although many of its molecular characteristics differ from connexins (important role for pannexin glycosylation in trafficking) |
|
has kinetics and dynamics that make it unique to serve distinct functions separate from connexin-based channels |
|
activates the inflammasome in neurons and astrocytes |
|
like connexins, may play an important role in hearing |
|
PANX1 hemichannels and P2RX1 and P2RX4 facilitate ATP release and autocrine feedback mechanisms that control Ca(2+) entry and T-cell activation at the immune synapse |
|
mediator of find-me signal/nucleotide release from apoptotic cells |
|
plasma membrane channel mediating the regulated release of find-me signals and selective plasma membrane permeability during apoptosis, with a new mechanism of activation by caspases |
|
implicated in ATP-mediated auto-/paracrine signaling, and having a crucial role potential in several cell death pathways |
|
constitutes the large conductance cation channel of cardiac myocytes, and PANX1 channels potentially promote arrhythmogenic activities |
|
not only facilitates growth of the primary tumor but further enhances the ability of tumor cells to metastasize |
|
PANX1 channels in the kidney may regulate ATP release and via purinergic signaling may participate in the control of renal epithelial fluid and electrolyte transport and vascular functions |
|
ATP release through PANX1 channels plays a critical role in maintaining synaptic strength and plasticity in CA1 neurons of the adult hippocampus |
|
PANX1 channels may play an important role in mediating gut function and in inflammatory bowel diseases (IBD) pathophysiology |
|
controls cellular properties of keratinocytes and dermal fibroblasts during early stages of skin development and modulates wound repair upon injury |
|
PANX1 and PANX3 are co-expressed in human skeletal muscle myoblasts and play a pivotal role in dictating the proliferation and differentiation status of these cells |
|
is a large-pore membrane channel involved in the release of ATP and other signaling mediators (pMID: 25925949) |
|
gap junction gene in vertebrates whose proteins mainly function as non-junctional channels on the cell surface |
|
is involved in chronic pain signaling by interacting with NMDAR in neurons and with P2RX7 in glia |
|
role for PANX1 channels in promoting leukocyte adhesion and emigration through the venous wall during acute systemic inflammation |
|
PANX1 channel activity regulates insulin-stimulated glucose uptake in adipocytes and thus contributes to control of metabolic homeostasis |
|
NXF2 and its co-factor, NXT1, form a complex with PANX1 and are required for co-transcriptional silencing of transposons in somatic and germline cells of the ovary |
