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FLASH GENE

Symbol

FBXO32

contributors: mct - updated : 25-10-2014

HGNC name	F-box only protein 32
HGNC id	16731

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   epigenetically silenced in ovarian cancer cell lines with disrupted TGFB1/SMAD4 signaling, and its methylation status predicts survival in patients with ovarian cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	induced in fasted mice
	mice lacking atrogin-1 failed to degrade Chmp2b, resulting in autophagy impairment, intracellular protein aggregate accumulation, unfolded protein response activation, and subsequent cardiomyocyte apoptosis, all of which increased progressively with age