protein
| interacts with calcineurin A and alpha-actinin-2 at the Z-disc of cardiomyocytes (decreases levels of calcineurin A and promotes its ubiquitination, leading to inhibition of cardiac hypertrophy in response to pathologic stimuli) |
|
interacting with EIF3F (highly conserved C-terminal domain is implicated for FBXO32-directed polyubiquitination and proteasomal degradation) |
|
rapid suppression of MYOD1 by FBXO32 seems to be a major event leading to skeletal muscle wasting |
|
MYOG interacted with FBXO32 (FBXO32 activated polyubiquitination of MYOG) |
|
not only associates with myosin heavy and light chain, but it also ubiquitinates these sarcomeric proteins 1) |
|
is the predominant E3 ligase through which MSTN manifests skeletal muscle wasting 1) |
|
putatively interacts with sarcomeric proteins, transcriptional factors, metabolic enzymes, components of translation, and spliceosome formation |
|
desmin and vimentin, two components of the intermediate filament in muscle, directly interacted with and were degraded by FBXO32 in response to MSTN |
|
EIF3F is a target of the E3 ubiquitin ligase FBXO32 for proteasome-mediated breakdown under atrophic conditions |
|
CHMP2B is a target of FBXO32-mediated degradation |