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FLASH GENE

Symbol

CALR

contributors: mct/shn - updated : 02-05-2015

HGNC name	calreticulin
HGNC id	1455

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in Sjögren syndrome tumoral germinal mutation       are frequently found in patients with myelofibrosis (MF) and essential thrombocythemia and patients with homozygous CALR mutations had reduced MPO protein, but normal MPO messenger RNA (mRNA) levels(ET)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	angiogenic regulator in gastric cancer, can serve as a prognosis marker
Therapy target

ANIMAL & CELL MODELS