| SUBCELLULAR LOCALIZATION
| extracellular
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| intracellular
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| intracellular,cytoplasm,organelle,lumen
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,cytosolic,granule
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| intracellular,nucleus
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| text
| calcium binding protein of endoplasmic and sarcoplasmic reticulum |
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also found in cell surface (T cells), cytosol and in the exracellular matrix |
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associated with the lytic granules in the cytolytic T-lymphocytes |
| basic FUNCTION
| involved in the regulation of intracellular Ca2+ homeostasis and endoplasmic reticulum (ER) Ca2+ storage capacity ( |
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involved in the synthesis (folding) of many proteins (lectin-like chaperone) |
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key upstream regulator of calcineurin-dependent pathways during cardiac development |
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inhibiting activity of glucocorticoid and other nuclear hormone receptors |
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playing a role which involves chromatin dynamics on the surface of mitotic chromosomes and posible role as histone chaperone |
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negatively regulating the cell surface expression of cystic fibrosis transmembrane conductance regulator |
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having functions in Ca(2+) homeostasis of myocardiac disease |
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can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors ( |
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can inhibit AR and RAR transcriptional activities as well as RA-induced neuronal differentiation |
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important modulator of the regulation of gene transcription by nuclear hormone receptors |
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playing a key role in determining anticancer immune responses |
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a receptor for nuclear export and may regulate the transcriptional activity of steroid hormone receptors ( |
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role in thrombospondin signaling ( |
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deglycosylated major histocompatibility complex class I heavy chains ( |
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essential in early cardiac development and plays an important role in autoimmunity and cancer ( |
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promotes cell motility and enhances resistance to anoikis through STAT3-CTTN-Akt pathway in esophageal squamous cell carcinoma |
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enhancing B2 bradykinin receptor maturation and homodimerization |
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may inhibit growth and/or metastasis of prostate cancer cells |
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enhancing gastric cancer cell proliferation and migration |
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enhancing BDKRB2 maturation and heterodimerization with AGT |
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plays an important role in the MHC class I assembly pathway |
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can regulate CD1D expression |
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CALR levels could potentially regulate CD1D-mediated stimulation of NKT cells |
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key role in the quality control of class I-peptide complexes |
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functions as a calcium buffer in the ER |
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calcium-binding role in thick ascending limb of Henle's loop adaptation and survival under osmotic stress |
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soluble placental CNX may have a physiological chaperone function similar to that of CALR |
