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FLASH GENE

Symbol

SLCO1B1

contributors: mct - updated : 08-02-2011

HGNC name	solute carrier organic anion transporter family, member 1B1
HGNC id	10959

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to interindividual variability in the pharmacokinetics of olmesartan to risk of statin-induced myopathy

Variant & Polymorphism other	polymorphism L193R, mutant protein SLC21A6-L193R was retained intracellularly, and this single amino acid exchange abolished transport function
	polymorphism could contribute to the interindividual variability in the pharmacokinetics of olmesartan
	common variants are strongly associated with an increased risk of statin-induced myopathy

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS