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FLASH GENE
Symbol SLCO1B1 contributors: mct - updated : 08-02-2011
HGNC name solute carrier organic anion transporter family, member 1B1
HGNC id 10959
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   moderately
Digestiveliver     Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Digestivehepatocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • twelve transmembrane domains, and transmembrane domain 10 (TM10) is critical for its function
  • N-glycosylation sites
  • two potential phosphorylation sites
  • conserved AAs R57, K361 and R580 seem to be part of the substrate binding sites and/or translocation pathways
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to C.elegans y32f6b1
    Homologene
    FAMILY
  • SLC21A superfamily of solute carriers
  • organo anion transporter family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text expressed on the sinusoidal membrane of human hepatocytes
    basic FUNCTION
  • transport of conjugated steroids (17beta glucoronosyl estradid, 3(H) estrone-3-sulfate, eicosanoids and thyroid hormones)
  • transporter of exogenous substance : bromosulfphophtalein, and predominantly involved in hepatic uptake of pravastatin
  • playing a role in prevention of hyperbilirubinemia by facilitating entry of unconjugated bilirubin in hepatocytes
  • involved in the hepatocellular uptake of a variety of endogenous and xenobiotic substances and drugs
  • plays an important role in the hepatic uptake of bile acids
  • plays a role in the pharmacokinetics of olmesartan, and the co-administration of olmesartan does not affect the pharmacokinetics of pravastatin or its metabolite
  • genetically polymorphic influx transporter which mediates the hepatic uptake of many endogenous compounds and xenobiotics
  • plays a major role in the hepatic uptake of drugs
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    text organic anion transport
    PATHWAY
    metabolism porphyrin/heme
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction of porphyrins with SLCO1B1, and tetrapyrroles are transported by SLCO1B1
  • cell & other
    REGULATION
    Other regulated by HNF1A
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to interindividual variability in the pharmacokinetics of olmesartan
  • to risk of statin-induced myopathy
  • Variant & Polymorphism other
  • polymorphism L193R, mutant protein SLC21A6-L193R was retained intracellularly, and this single amino acid exchange abolished transport function
  • polymorphism could contribute to the interindividual variability in the pharmacokinetics of olmesartan
  • common variants are strongly associated with an increased risk of statin-induced myopathy
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS