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FLASH GENE

Symbol

SLCO1B1

contributors: mct - updated : 08-02-2011

HGNC name	solute carrier organic anion transporter family, member 1B1
HGNC id	10959

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	12p12.2      Physical location : 21.284.127 - 21.392.728
Synonym name	liver specific transporter 1
	solute carrier family 21 (organic anion transporter), member 6
	sodium-independent organic anion-transporting polypeptide 2
Synonym symbol(s)	LST1, OATP2, OATPC, OAT6, SLC21A6, OATP1B1, MGC133282

DNA

TYPE	functioning gene
STRUCTURE	108.60 kb     15 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006446 15 - 2800 NP_006437 - 691 - 2000 10779507 variant 2 - splicing 4800 isoform 2 - - only in liver, basolateral membranes of hepatocytes 2000 10779507

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen       moderately Digestive liver         Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Digestive hepatocyte Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	twelve transmembrane domains, and transmembrane domain 10 (TM10) is critical for its function
	N-glycosylation sites
	two potential phosphorylation sites
	conserved AAs R57, K361 and R580 seem to be part of the substrate binding sites and/or translocation pathways

conjugated

GlycoP

HOMOLOGY

interspecies

homolog to C.elegans y32f6b1

Homologene

FAMILY	SLC21A superfamily of solute carriers
	organo anion transporter family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	plasma membrane
text	expressed on the sinusoidal membrane of human hepatocytes

basic FUNCTION	transport of conjugated steroids (17beta glucoronosyl estradid, 3(H) estrone-3-sulfate, eicosanoids and thyroid hormones)
	transporter of exogenous substance : bromosulfphophtalein, and predominantly involved in hepatic uptake of pravastatin
	playing a role in prevention of hyperbilirubinemia by facilitating entry of unconjugated bilirubin in hepatocytes
	involved in the hepatocellular uptake of a variety of endogenous and xenobiotic substances and drugs
	plays an important role in the hepatic uptake of bile acids
	plays a role in the pharmacokinetics of olmesartan, and the co-administration of olmesartan does not affect the pharmacokinetics of pravastatin or its metabolite
	genetically polymorphic influx transporter which mediates the hepatic uptake of many endogenous compounds and xenobiotics
	plays a major role in the hepatic uptake of drugs

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

active transport

text	organic anion transport

PATHWAY

metabolism

porphyrin/heme

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interaction of porphyrins with SLCO1B1, and tetrapyrroles are transported by SLCO1B1

cell & other

REGULATION

Other

regulated by HNF1A

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to interindividual variability in the pharmacokinetics of olmesartan to risk of statin-induced myopathy

Variant & Polymorphism other	polymorphism L193R, mutant protein SLC21A6-L193R was retained intracellularly, and this single amino acid exchange abolished transport function
	polymorphism could contribute to the interindividual variability in the pharmacokinetics of olmesartan
	common variants are strongly associated with an increased risk of statin-induced myopathy

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS