Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NDRG1 contributors: mct - updated : 31-01-2013
HGNC name N-myc downstream regulated 1
HGNC id 7679
ASSOCIATED DISORDERS
corresponding disease(s) CMT4D
related resource Mutation Database of Inherited Peripheral Neuropathies
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
in colorectal neoplasmand in renal carcinoma
tumoral     --over  
associated with angiogenesis and may be a poor prognostic indicator in women with cervical adenocarcinoma
tumoral fusion      
NDRG1-ERG fusion in prostate carcinoma is predicted to encode a chimeric protein
tumoral     --low  
in glioma
constitutional     --over  
led to decreased expression of the Wnt-responsive gene, CCND1 which drives cell cycle progression
Susceptibility
Variant & Polymorphism
Candidate gene
Marker could be developed as a marker contributing to diagnosis and evaluating prognosis in gastric cancer
Therapy target
SystemTypeDisorderPubmed
cancerdigestivestomach
potential therapeutic target of gastric cancer
ANIMAL & CELL MODELS
being up-regulated in N-Myc knockout mouse embryos