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FLASH GENE
Symbol NDRG1 contributors: mct - updated : 31-01-2013
HGNC name N-myc downstream regulated 1
HGNC id 7679
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue  highly
 pharynx   highly
Lymphoid/Immunethymus   highly
Nervousbrain   moderately
Reproductivemale systemprostate  moderately
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunelymphocyte
Nervousastrocyte
Nervousoligodendrocyte
NervousPurkinje cell
NervousSchwann cell
cell lineage
cell lines most cancer cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain
PROTEIN
PHYSICAL PROPERTIES Hydrophilic
STRUCTURE
motifs/domains
  • three repeated highly hydrophilic amino acid sequence motifs at C terminus
  • a putative phosphopantotheine binding site
  • HOMOLOGY
    interspecies homolog to rattus Ndrg1 (93.4 pc)
    homolog to murine Ndrg1 (93.7 pc)
    Homologene
    FAMILY
  • alpha/beta hydrolase superfamily
  • N-myc downregulated gene (NDRG) family
  • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    text
  • localized in the cytoplasme of myelinating Schwann cells and oligodendrocytes, and in basolateral membranes of gut lumen surface epithelial cells
  • predominantly cytosolic
  • basic FUNCTION
  • TP53-regulated gene, involved in growth arrest, cell differentiation and playing a growth inhibitory role
  • playing mainly a crucial function in the development and/or maintenance of peripheral nerves
  • mast cell maturation-associated inducible protein that allows the cells to be susceptible to extracellular stimuli leading to degranulation
  • playing a necessary but not sufficient role for TP53-mediated caspase activation and apoptosis
  • playing a putative role in the general mechanisms of HDL-mediated cholesterol transport
  • involbed in stress responses, hormone responses, cell growth, and differentiation
  • intracellular protein associated with stress response, cell growth, and differentiation
  • may play a partially redundant role in specific cells in the brain
  • nickel- and calcium-inducible gene that plays important roles in the primary growth of malignant tumors, as well as in invasion and metastasis, most likely through its ability to induce cellular differentiation
  • may play an inhibitory role during the development of glioma and may be a potential prognosis predictor of glioma
  • importance of NDRG1 as a growth control gene in breast tissue
  • differentiation-related gene that plays important roles in cell differentiation, organ formation, and embryonic development
  • plays a significant role in invasion and metastasis of cancer
  • up-regulated CD82 expression through modulation of ATF3 signaling in prostate cancer cells
  • involved in tumor adaptation to reoxygenation
  • is an iron-regulated metastasis suppressor which is up-regulated by iron depletion and may be involved in the epithelial-mesenchymal transition (EMT)
  • is involved in the EMT through the SMAD and Wnt pathways
  • SGK1 and NDRG1 participate in the regulation of NFKB1 signaling and maturation of dendritic cells (DCs)
  • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    text
  • differentiation of Schwann cells
  • mast cell activation
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with APO A-I and A-II
  • binding to phosphopantetheine
  • TBX2 targets NDRG1 through a previously undescribed mechanism involving the recruitment of early growth response 1 (EGR1)
  • CD82 is a functional downstream target of the NDRG1 pathway
  • upregulates neural precursor cell expressed developmentally downregulated 4-like (NEDD4L) and GLI-similar-3 (GLIS3)
  • cell & other
    REGULATION
    activated by strongly up-regulated by chemical iron chelators and hypoxia
    induced by nickel (Ni2+ compounds), homocysteine, 2-mercaptoethanol and tunicamycin
    inhibited by VHL (von Hippel-Lindau tumor suppressor protein) in renal cancer cells
    repressed by both N-Myc and c-Myc via interaction with the core promoter
    Phosphorylated by the protein kinase SGK1, and is temporally and spatially controlled during the cell cycle, suggesting a role for NDRG1 in successful mitosis
    ASSOCIATED DISORDERS
    corresponding disease(s) CMT4D
    related resource Mutation Database of Inherited Peripheral Neuropathies
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in colorectal neoplasmand in renal carcinoma
    tumoral     --over  
    associated with angiogenesis and may be a poor prognostic indicator in women with cervical adenocarcinoma
    tumoral fusion      
    NDRG1-ERG fusion in prostate carcinoma is predicted to encode a chimeric protein
    tumoral     --low  
    in glioma
    constitutional     --over  
    led to decreased expression of the Wnt-responsive gene, CCND1 which drives cell cycle progression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker could be developed as a marker contributing to diagnosis and evaluating prognosis in gastric cancer
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivestomach
    potential therapeutic target of gastric cancer
    ANIMAL & CELL MODELS
    being up-regulated in N-Myc knockout mouse embryos