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FLASH GENE
Symbol NDRG1 contributors: mct - updated : 31-01-2013
HGNC name N-myc downstream regulated 1
HGNC id 7679
RNA
TRANSCRIPTS type messenger
text both variants 1 and 2 encode the same protein
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 splicing 3520 42.7 394 - 2004 15377670
16 splicing 3123 42.7 394 - 2004 15377670
using an alternate splice site in the 5' UTR
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue  highly
 pharynx   highly
Lymphoid/Immunethymus   highly
Nervousbrain   moderately
Reproductivemale systemprostate  moderately
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunelymphocyte
Nervousastrocyte
Nervousoligodendrocyte
NervousPurkinje cell
NervousSchwann cell
cell lineage
cell lines most cancer cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain
PROTEIN
PHYSICAL PROPERTIES Hydrophilic
STRUCTURE
motifs/domains
  • three repeated highly hydrophilic amino acid sequence motifs at C terminus
  • a putative phosphopantotheine binding site
  • HOMOLOGY
    interspecies homolog to rattus Ndrg1 (93.4 pc)
    homolog to murine Ndrg1 (93.7 pc)
    Homologene
    FAMILY
  • alpha/beta hydrolase superfamily
  • N-myc downregulated gene (NDRG) family
  • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    text
  • localized in the cytoplasme of myelinating Schwann cells and oligodendrocytes, and in basolateral membranes of gut lumen surface epithelial cells
  • predominantly cytosolic
  • basic FUNCTION
  • TP53-regulated gene, involved in growth arrest, cell differentiation and playing a growth inhibitory role
  • playing mainly a crucial function in the development and/or maintenance of peripheral nerves
  • mast cell maturation-associated inducible protein that allows the cells to be susceptible to extracellular stimuli leading to degranulation
  • playing a necessary but not sufficient role for TP53-mediated caspase activation and apoptosis
  • playing a putative role in the general mechanisms of HDL-mediated cholesterol transport
  • involbed in stress responses, hormone responses, cell growth, and differentiation
  • intracellular protein associated with stress response, cell growth, and differentiation
  • may play a partially redundant role in specific cells in the brain
  • nickel- and calcium-inducible gene that plays important roles in the primary growth of malignant tumors, as well as in invasion and metastasis, most likely through its ability to induce cellular differentiation
  • may play an inhibitory role during the development of glioma and may be a potential prognosis predictor of glioma
  • importance of NDRG1 as a growth control gene in breast tissue
  • differentiation-related gene that plays important roles in cell differentiation, organ formation, and embryonic development
  • plays a significant role in invasion and metastasis of cancer
  • up-regulated CD82 expression through modulation of ATF3 signaling in prostate cancer cells
  • involved in tumor adaptation to reoxygenation
  • is an iron-regulated metastasis suppressor which is up-regulated by iron depletion and may be involved in the epithelial-mesenchymal transition (EMT)
  • is involved in the EMT through the SMAD and Wnt pathways
  • SGK1 and NDRG1 participate in the regulation of NFKB1 signaling and maturation of dendritic cells (DCs)
  • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    text
  • differentiation of Schwann cells
  • mast cell activation
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with APO A-I and A-II
  • binding to phosphopantetheine
  • TBX2 targets NDRG1 through a previously undescribed mechanism involving the recruitment of early growth response 1 (EGR1)
  • CD82 is a functional downstream target of the NDRG1 pathway
  • upregulates neural precursor cell expressed developmentally downregulated 4-like (NEDD4L) and GLI-similar-3 (GLIS3)
  • cell & other
    REGULATION
    activated by strongly up-regulated by chemical iron chelators and hypoxia
    induced by nickel (Ni2+ compounds), homocysteine, 2-mercaptoethanol and tunicamycin
    inhibited by VHL (von Hippel-Lindau tumor suppressor protein) in renal cancer cells
    repressed by both N-Myc and c-Myc via interaction with the core promoter
    Phosphorylated by the protein kinase SGK1, and is temporally and spatially controlled during the cell cycle, suggesting a role for NDRG1 in successful mitosis
    ASSOCIATED DISORDERS
    corresponding disease(s) CMT4D
    related resource Mutation Database of Inherited Peripheral Neuropathies
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in colorectal neoplasmand in renal carcinoma
    tumoral     --over  
    associated with angiogenesis and may be a poor prognostic indicator in women with cervical adenocarcinoma
    tumoral fusion      
    NDRG1-ERG fusion in prostate carcinoma is predicted to encode a chimeric protein
    tumoral     --low  
    in glioma
    constitutional     --over  
    led to decreased expression of the Wnt-responsive gene, CCND1 which drives cell cycle progression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker could be developed as a marker contributing to diagnosis and evaluating prognosis in gastric cancer
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivestomach
    potential therapeutic target of gastric cancer
    ANIMAL & CELL MODELS
    being up-regulated in N-Myc knockout mouse embryos