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FLASH GENE
Symbol CPEB3 contributors: mct/npt - updated : 23-06-2012
HGNC name cytoplasmic polyadenylation element binding protein 3
HGNC id 21746
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal glutamine-rich domain
  • two RRM (RNA recognition motif) domains
  • conserved nuclear export signals that are not present in CPEB
  • a C-terminal zinc finger domain, and RNA-binding domain of CPEB3 binds to the C-terminal unstructured region of TOB1
    • HOMOLOGY
    interspecies homolog to murine ApCPEB (98 pc)
    Homologene
    FAMILY
  • RRM CPEB family
    • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • nucleocytoplasm-shuttling protein with predominant residence in the cytoplasm, whereas activation of NMDA receptors accumulates CPEB3 in the nucleus
  • nucleus-cytoplasm shuttling protein retained in the nucleus in response to calcium-mediated signaling and alpha-calcium/calmodulin-dependent kinase protein II (CaMKII) activity
  • CPEB3 and NEURL1 colocalize along the apical dendrites of adult CA1 neurons, in opposition to Synaptophysin
    • basic FUNCTION
  • involved in some forms of synaptic plasticity
  • promotes polyadenylation-induced translation in oocytes and neurons
  • role for CPEB3 in human episodic memory
  • regulate translation by binding to regulatory motifs of defined mRNA targets
  • RNA-binding protein that participates in translational control
  • sequence-specific translational regulatory protein
  • regulates translation in neurons, albeit probably not through polyadenylation
  • sequence-specific RNA-binding protein and represses translation of its target mRNAs in neurons (
  • has a novel function in the nucleus as to suppress STAT5B-dependent EGFR gene transcription
  • negatively regulates the expression of a target by accelerating deadenylation and decay of its mRNA, which it achieves by tethering to the mRNA
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding to the cytoplasmic polyadenylation element (CPE)
    small molecule
    protein
  • EGFR, is a target gene transcriptionally activated by STAT5B and downregulated by CPEB3 in neurons (
  • TOB1 binds directly to CPEB3 (binds CNOT8 deadenylase and recruits it to CPEB3 to form a ternary complex)
  • NEURL and ubiquitin modulate CPEB3-dependent translation of GRIA1 and GRIA2
  • CAPN2 activated through NMDAR signaling cleaves CPEB3 and abrogates CPEB3-repressed translation in neurons (
    • cell & other
    REGULATION
    activated by Neuralized1, an E3 ubiquitin ligase
    Other regulated by endogenous miRNAs that co-regulate CPEB2, CPEB3 and CPEB4 transcripts
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS