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FLASH GENE
Symbol CPEB3 contributors: mct/npt - updated : 23-06-2012
HGNC name cytoplasmic polyadenylation element binding protein 3
HGNC id 21746
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver   moderately
 stomach   highly
Endocrinepancreas   highly
 thyroid   highly
Reproductivemale systemprostate  moderately
Respiratoryrespiratory tractlarynx  predominantly
Visualeye   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscular   moderately
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
Text
  • potentially up-regulated in the retina during development
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal glutamine-rich domain
  • two RRM (RNA recognition motif) domains
  • conserved nuclear export signals that are not present in CPEB
  • a C-terminal zinc finger domain, and RNA-binding domain of CPEB3 binds to the C-terminal unstructured region of TOB1
  • HOMOLOGY
    interspecies homolog to murine ApCPEB (98 pc)
    Homologene
    FAMILY
  • RRM CPEB family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • nucleocytoplasm-shuttling protein with predominant residence in the cytoplasm, whereas activation of NMDA receptors accumulates CPEB3 in the nucleus
  • nucleus-cytoplasm shuttling protein retained in the nucleus in response to calcium-mediated signaling and alpha-calcium/calmodulin-dependent kinase protein II (CaMKII) activity
  • CPEB3 and NEURL1 colocalize along the apical dendrites of adult CA1 neurons, in opposition to Synaptophysin
  • basic FUNCTION
  • involved in some forms of synaptic plasticity
  • promotes polyadenylation-induced translation in oocytes and neurons
  • role for CPEB3 in human episodic memory
  • regulate translation by binding to regulatory motifs of defined mRNA targets
  • RNA-binding protein that participates in translational control
  • sequence-specific translational regulatory protein
  • regulates translation in neurons, albeit probably not through polyadenylation
  • sequence-specific RNA-binding protein and represses translation of its target mRNAs in neurons (
  • has a novel function in the nucleus as to suppress STAT5B-dependent EGFR gene transcription
  • negatively regulates the expression of a target by accelerating deadenylation and decay of its mRNA, which it achieves by tethering to the mRNA
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding to the cytoplasmic polyadenylation element (CPE)
    small molecule
    protein
  • EGFR, is a target gene transcriptionally activated by STAT5B and downregulated by CPEB3 in neurons (
  • TOB1 binds directly to CPEB3 (binds CNOT8 deadenylase and recruits it to CPEB3 to form a ternary complex)
  • NEURL and ubiquitin modulate CPEB3-dependent translation of GRIA1 and GRIA2
  • CAPN2 activated through NMDAR signaling cleaves CPEB3 and abrogates CPEB3-repressed translation in neurons (
  • cell & other
    REGULATION
    activated by Neuralized1, an E3 ubiquitin ligase
    Other regulated by endogenous miRNAs that co-regulate CPEB2, CPEB3 and CPEB4 transcripts
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS