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FLASH GENE

Symbol

CPEB3

contributors: mct/npt - updated : 23-06-2012

HGNC name	cytoplasmic polyadenylation element binding protein 3
HGNC id	21746

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive liver       moderately   stomach       highly Endocrine pancreas       highly   thyroid       highly Reproductive male system prostate     moderately Respiratory respiratory tract larynx     predominantly Visual eye       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular       moderately

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

Text	potentially up-regulated in the retina during development

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an N-terminal glutamine-rich domain
	two RRM (RNA recognition motif) domains
	conserved nuclear export signals that are not present in CPEB
	a C-terminal zinc finger domain, and RNA-binding domain of CPEB3 binds to the C-terminal unstructured region of TOB1

HOMOLOGY

interspecies

homolog to murine ApCPEB (98 pc)

Homologene

FAMILY

RRM CPEB family

CATEGORY

RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus
text	nucleocytoplasm-shuttling protein with predominant residence in the cytoplasm, whereas activation of NMDA receptors accumulates CPEB3 in the nucleus
	nucleus-cytoplasm shuttling protein retained in the nucleus in response to calcium-mediated signaling and alpha-calcium/calmodulin-dependent kinase protein II (CaMKII) activity
	CPEB3 and NEURL1 colocalize along the apical dendrites of adult CA1 neurons, in opposition to Synaptophysin

basic FUNCTION	involved in some forms of synaptic plasticity
	promotes polyadenylation-induced translation in oocytes and neurons
	role for CPEB3 in human episodic memory
	regulate translation by binding to regulatory motifs of defined mRNA targets
	RNA-binding protein that participates in translational control
	sequence-specific translational regulatory protein
	regulates translation in neurons, albeit probably not through polyadenylation
	sequence-specific RNA-binding protein and represses translation of its target mRNAs in neurons (
	has a novel function in the nucleus as to suppress STAT5B-dependent EGFR gene transcription
	negatively regulates the expression of a target by accelerating deadenylation and decay of its mRNA, which it achieves by tethering to the mRNA

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA	binding to the cytoplasmic polyadenylation element (CPE)

small molecule

protein	EGFR, is a target gene transcriptionally activated by STAT5B and downregulated by CPEB3 in neurons (
	TOB1 binds directly to CPEB3 (binds CNOT8 deadenylase and recruits it to CPEB3 to form a ternary complex)
	NEURL and ubiquitin modulate CPEB3-dependent translation of GRIA1 and GRIA2
	CAPN2 activated through NMDAR signaling cleaves CPEB3 and abrogates CPEB3-repressed translation in neurons (

cell & other

REGULATION

activated by

Neuralized1, an E3 ubiquitin ligase

Other

regulated by endogenous miRNAs that co-regulate CPEB2, CPEB3 and CPEB4 transcripts

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS