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FLASH GENE
Symbol CPEB3 contributors: mct/npt - updated : 23-06-2012
HGNC name cytoplasmic polyadenylation element binding protein 3
HGNC id 21746
Location 10q23.32      Physical location : 93.808.398 - 94.050.875
Synonym name
  • related to C elegans hypothetical 42.4kDa protein, C40H1.1
  • CPE-binding protein 3
    • Synonym symbol(s) KIAA0940, CPE-BP3
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem, gene in gene
    text an 81-nucleotide ribozyme contained in the intron 3
    STRUCTURE 242.48 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    text
  • two alternatively spliced transcripts produced by the use of an alternate untranslated first exons, one expressed in liver and testis, and the other expressed in brain
  • the self-cleaving ribozyme is structurally related to ribozymes from human hepatitis delta virus (HDV), a single-stranded RNA satellite virus for hepatitis B infection (Salehi-Ashtiani et al, 2006)
    • identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 5753 - 684 - 2006 16990549
    10 - 5877 76 698 - 2006 16990549
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver   moderately
     stomach   highly
    Endocrinepancreas   highly
     thyroid   highly
    Reproductivemale systemprostate  moderately
    Respiratoryrespiratory tractlarynx  predominantly
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscular   moderately
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    Text
  • potentially up-regulated in the retina during development
    • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal glutamine-rich domain
  • two RRM (RNA recognition motif) domains
  • conserved nuclear export signals that are not present in CPEB
  • a C-terminal zinc finger domain, and RNA-binding domain of CPEB3 binds to the C-terminal unstructured region of TOB1
    • HOMOLOGY
    interspecies homolog to murine ApCPEB (98 pc)
    Homologene
    FAMILY
  • RRM CPEB family
    • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • nucleocytoplasm-shuttling protein with predominant residence in the cytoplasm, whereas activation of NMDA receptors accumulates CPEB3 in the nucleus
  • nucleus-cytoplasm shuttling protein retained in the nucleus in response to calcium-mediated signaling and alpha-calcium/calmodulin-dependent kinase protein II (CaMKII) activity
  • CPEB3 and NEURL1 colocalize along the apical dendrites of adult CA1 neurons, in opposition to Synaptophysin
    • basic FUNCTION
  • involved in some forms of synaptic plasticity
  • promotes polyadenylation-induced translation in oocytes and neurons
  • role for CPEB3 in human episodic memory
  • regulate translation by binding to regulatory motifs of defined mRNA targets
  • RNA-binding protein that participates in translational control
  • sequence-specific translational regulatory protein
  • regulates translation in neurons, albeit probably not through polyadenylation
  • sequence-specific RNA-binding protein and represses translation of its target mRNAs in neurons (
  • has a novel function in the nucleus as to suppress STAT5B-dependent EGFR gene transcription
  • negatively regulates the expression of a target by accelerating deadenylation and decay of its mRNA, which it achieves by tethering to the mRNA
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding to the cytoplasmic polyadenylation element (CPE)
    small molecule
    protein
  • EGFR, is a target gene transcriptionally activated by STAT5B and downregulated by CPEB3 in neurons (
  • TOB1 binds directly to CPEB3 (binds CNOT8 deadenylase and recruits it to CPEB3 to form a ternary complex)
  • NEURL and ubiquitin modulate CPEB3-dependent translation of GRIA1 and GRIA2
  • CAPN2 activated through NMDAR signaling cleaves CPEB3 and abrogates CPEB3-repressed translation in neurons (
    • cell & other
    REGULATION
    activated by Neuralized1, an E3 ubiquitin ligase
    Other regulated by endogenous miRNAs that co-regulate CPEB2, CPEB3 and CPEB4 transcripts
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS