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FLASH GENE
Symbol EPN2 contributors: mct - updated : 27-04-2012
HGNC name epsin 2
HGNC id 18639
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal module composed of epsin NH2 terminal homology domain
  • epsin N-terminal homology (ENTH) domain (ENTH domains comprise multiple alpha-helices folded upon each other to form a compact globular structure that has been implicated in interactions with lipids and proteins) (Pubmed 12750376)
  • a VHS domain,at the central region
  • multiple DPW motifs
  • two clathrin binding sequences
  • several Eps15 homology (EH) domain binding motif that function in vesicular trafficking and endocytosis
  • three C terminal NPF motifs
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • peri-Golgi region
  • partially colocalized with clathrin
    • basic FUNCTION
  • implicated in membrane dynamics at the cell surfaces
  • involved in the regulation of endocytosis
  • endocytic adaptor with putative functions in general aspects of clathrin-mediated endocytosis as well as in the internalization of specific membrane proteins
  • role of epsin as a specialized endocytic adaptor, with a critical role in the activation of Notch signaling
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • clathrin adaptor AP-2
  • clathrin
  • EPS15
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS