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FLASH GENE
Symbol EPN2 contributors: mct - updated : 27-04-2012
HGNC name epsin 2
HGNC id 18639
Location 17p11.2      Physical location : 19.140.689 - 19.240.027
Synonym name
  • EPS-15-interacting protein 2
  • Synonym symbol(s) KIAA1065, EHB21
    DNA
    TYPE anonymous DNA segment
    STRUCTURE 99.34 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 4835 - 641 - 2003 12750376
    10 - 4664 - 584 - 2003 12750376
    8 - 3776 - 356 - 2003 12750376
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Reproductivefemale systemovary   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal module composed of epsin NH2 terminal homology domain
  • epsin N-terminal homology (ENTH) domain (ENTH domains comprise multiple alpha-helices folded upon each other to form a compact globular structure that has been implicated in interactions with lipids and proteins) (Pubmed 12750376)
  • a VHS domain,at the central region
  • multiple DPW motifs
  • two clathrin binding sequences
  • several Eps15 homology (EH) domain binding motif that function in vesicular trafficking and endocytosis
  • three C terminal NPF motifs
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • peri-Golgi region
  • partially colocalized with clathrin
  • basic FUNCTION
  • implicated in membrane dynamics at the cell surfaces
  • involved in the regulation of endocytosis
  • endocytic adaptor with putative functions in general aspects of clathrin-mediated endocytosis as well as in the internalization of specific membrane proteins
  • role of epsin as a specialized endocytic adaptor, with a critical role in the activation of Notch signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • clathrin adaptor AP-2
  • clathrin
  • EPS15
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS