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FLASH GENE

Symbol

EPN2

contributors: mct - updated : 27-04-2012

HGNC name	epsin 2
HGNC id	18639

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	anonymous DNA segment
STRUCTURE	99.34 kb     11 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014964 11 - 4835 NP_055779 - 641 - 2003 12750376 NM_148921 10 - 4664 NP_683723 - 584 - 2003 12750376 NM_001102664 8 - 3776 NP_001096134 - 356 - 2003 12750376

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Reproductive female system ovary

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal module composed of epsin NH2 terminal homology domain
	epsin N-terminal homology (ENTH) domain (ENTH domains comprise multiple alpha-helices folded upon each other to form a compact globular structure that has been implicated in interactions with lipids and proteins) (Pubmed 12750376)
	a VHS domain,at the central region
	multiple DPW motifs
	two clathrin binding sequences
	several Eps15 homology (EH) domain binding motif that function in vesicular trafficking and endocytosis
	three C terminal NPF motifs

HOMOLOGY

Homologene

FAMILY

CATEGORY

adaptor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,cytosolic,vesicle
text	peri-Golgi region
	partially colocalized with clathrin

basic FUNCTION	implicated in membrane dynamics at the cell surfaces
	involved in the regulation of endocytosis
	endocytic adaptor with putative functions in general aspects of clathrin-mediated endocytosis as well as in the internalization of specific membrane proteins
	role of epsin as a specialized endocytic adaptor, with a critical role in the activation of Notch signaling

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	clathrin adaptor AP-2
	clathrin
	EPS15

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS