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FLASH GENE
Symbol DYRK1B contributors: mct/pg - updated : 01-10-2010
HGNC name dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
HGNC id 3092
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a bipartite nuclear localization signal (NLS)
  • a putative leucine zipper motif and a conserved histidine repeat
    • HOMOLOGY
    interspecies homolog to Drosophila minibrain
    homolog to murine Dres27
    Homologene
    FAMILY
  • protein kinase superfamily
  • Dyrk/Minibrain family of dual-specificity kinases
  • CMGC Ser/Thr protein kinase family
  • MNB/DYRK subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • serine/threonine and tyrosine kinase,involved in the regulation of nuclear functions
  • multifunctional Ser/Thr kinase that plays a critical role in muscle differentiation by regulatory effects on motility, transcription, cell cycle progression, and cell survival
  • acts as a survival factor in lung cancer cells
  • putatively involved in cell growth and development
  • effector molecule of activated RAS
  • involved in linking mutant RAS to the inhibition of canonical HH signaling
  • mediates cell cycle and survival via interacting with MAPK/ERK signals and simultaneous inhibition of both pathways
  • mediates G0/G1 to S phase cell cycle progression and cell survival involving MAPK/ERK signaling in human cancer cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • CIRBP forms a complex together with DYRK1B and CCND1
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HNF1A (an HNF1alpha transcriptional activator in response to an MKK3-mediated stress signal, and the selective expression of DCOHM could restrict the DYRK1B response to carcinoma cells)
  • DCOHM (DYRK1B binding protein)
  • blocks quiescent cells from traversing G1 phase of the cell cycle by phosphorylating and destabilizing CCND1 and CCND3
  • DYRK1A, DYRK1B, bind to the evolutionary conserved DCAF7 protein
  • NKX3-1 and DYRK1B were shown to interact via the DYRK1B kinase domain
  • critical positive regulator of HH/GLI signaling downstream of SMO
    • cell & other
    REGULATION
    activated by MAP2K3
    ASSOCIATED DISORDERS
    corresponding disease(s) AOMS3
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colon carcinoma
    tumoral     --over  
    in solid tumors and mediates cell survival in colon cancer, pancreatic ductal adenocarcinoma and rhabdomyosarcomas
    constitutional        
    -
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerbone 
    promising target for molecular therapy in the treatment of osteosarcoma
    cancerlung 
    may be a novel therapeutic target in lung cancer
    cancer  
    may be a novel therapeutic target for human cancer
    ANIMAL & CELL MODELS